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https://en.wikipedia.org/wiki/Default_mode_network#Modulation
http://www.econtalk.org/michael-pollan-on-psychedelic-drugs-and-how-to-change-your-mind/

In neuroscience, the default mode network (DMN), also default network, or default state network, is a large scale brain network of interacting brain regions known to have activity highly correlated with each other and distinct from other networks in the brain.[3]
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Meditation – Structural changes in areas of the DMN such as the temporoparietal junction, posterior cingulate cortex, and precuneus have been found in meditation practitioners.[31] There is reduced activation and reduced functional connectivity of the DMN in long-term practitioners.[31] Various forms of nondirective meditation, including Transcendental Meditation[32] and Acem Meditation,[33] have been found to activate the DMN.

Psychedelic drugs – Reduced blood flow to the PCC and mPFC was observed under the administration of psilocybin. These two areas are considered to be the main nodes of the DMN.[37] One study on the effects of LSD demonstrated that the drug desynchronizes brain activity within the DMN; the activity of the brain regions that constitute the DMN becomes less correlated.[38]

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